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What to Know About Hyaluronidase, the Filler Dissolver Doctors Swear By

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What to Know About Hyaluronidase, the Filler Dissolver Doctors Swear By featured image
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The best approach to filler is often a minimalist one. When it comes to cosmetic treatments, less is often more when it comes to adding volume. Overdoing it or poorly placed filler can alter the natural contours of your face. Luckily, there’s a solution if you’ve ended up with too much. Filler dissolver, powered by hyaluronidase, comes to the rescue. By breaking down hyaluronic acid, it allows your body to reabsorb filler, rectifying those troublesome issues.

But, it’s not a one-size-fits-all solution. Results can vary and patience is key—it may take a week or two to see the full effects. If you’re dissatisfied with your current filler situation, dissolving it could be a game-changer. Here’s how the pros do it.

What is hyaluronidase and how does it work? 

According to Fort Lauderdale, FL dermatologist Maryann Mikhail, MD, filler dissolver, also known as hyaluronidase, is an injectable enzyme that breaks down and dissolves hyaluronic acid fillers. “It works by cleaving the bonds that link together the hyaluronic acid molecules in the filler, causing the filler gel to turn back into a liquid that the body can then absorb and eliminate,” she says.

How long does it take to dissolve fillers? 

It can take anywhere from a few hours to a few days to start seeing results from filler-dissolving injections. “Complete dissolution of the filler may take multiple treatment sessions spaced two to four weeks apart, depending on the type and amount of filler as well as the area treated,” says New York dermatologist Marina Peredo, MD.

How many sessions of hyaluronidase does it take to dissolve filler? 

The number of hyaluronidase dissolution sessions needed can depend on several factors:

The type and amount of filler used: “More crosslinked, longer-lasting fillers like may require more sessions than less crosslinked fillers,” says Dr. Peredo. “Larger volumes of filler often need more sessions as well.” 

The location of the filler: Some areas like the lips may require more sessions to fully dissolve filler compared to other areas. “Individual response is also a factor,” says Palo Alto, CA plastic surgeon Sachin Parikh, MD. “Some people’s bodies break down filler more slowly so they require more sessions.”

What are the benefits of hyaluronidase injections? 

The benefits of filler dissolving include reversing overfilled or overcorrected areas, fixing asymmetry or irregularities and removing old filler before placing new filler for a refreshed look. “It gives us option to reverse or adjust filler results,” says Dr. Peredo.

What are the risks of hyaluronidase injections?

Potential risks include bruising, swelling, lumpiness and unevenness as the filler breaks down. There is a risk of under-correction if too much filler is dissolved. “Necrosis is a rare but serious risk if the dissolving agent enters a blood vessel, so injections should be done slowly with caution,” adds Dr. Mikhail.

How does filler dissolver reverse vascular occulusion?

Vascular occlusion, also known as filler occlusion, is a rare but serious complication that can occur during a dermal filler procedure. It happens when the filler substance obstructs a blood vessel, leading to reduced blood flow and potential tissue damage. Symptoms can include acute pain, blanching, swelling and color changes in the skin. Immediate treatment is crucial and may involve the administration of hyaluronidase to dissolve the filler, as well as other measures to increase blood flow and oxygen content to the affected tissues. 

Fresno, CA, dermatologist Kathleen Behr, MD emphasizes the critical importance of acting swiftly if occlusion occurs with filler. “You really want to do it right away. If you see blanching on the skin, we massage the area and inject hyaluronidase. Massage is crucial in trying to dissolve and address the issue promptly.”

If you’re considering dissolving filler, it’s important to consult with an expert injector to discuss your specific situation and the potential outcomes.

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