Here’s the truth: over-the-counter skin-care products can only do so much when it comes to fighting aging. There comes a time when all the retinol in the world won’t smooth out the lines between your brows, otherwise known as the ‘elevens.’ Enter Dysport (abobotulinumtoxinA)*: a neuromodulator to boost your wrinkle-smoothing efforts for moderate to severe frown lines between your brows. (*Please see Full Important Safety Information, including Distant Spread of Toxin Effect Boxed Warning at the end of this article.)
If you’ve never been injected with a neuromodulator, you might not be too familiar with Dysport. We talked to West Islip, NY board certified dermatologist Dr. Kavita Mariwalla to get the scoop on exactly what happens to those pesky wrinkles once you’ve been injected, the side effects to be aware of, and the results you can expect post-treatment.
First, what is Dysport?
To put it simply, Dysport is a brand of neuromodulator. Neuromodulators are prescription injections that can temporarily reduce the appearance of moderate to severe wrinkles in the face. “Like all neuromodulators, Dysport works on the communication signals at the level of the muscle to stop muscular contraction by disrupting the release of acetylcholine,” explains Dr. Mariwalla. “The result is that the muscles that cause wrinkles can’t contract, and the skin appears smoother and often wrinkle-free.”
What can you expect after a Dysport treatment?
The effects of Dysport may become visible in under a week. In fact, studies have shown that results typically appear in as little as two to three days after treatment.1-3† “As it starts to kick in, movements like furrowing the brows will start to diminish and the lines these movements make—like the ‘elevens’—will also start to fade,” Dr. Mariwalla explains. Dysport may last for up to five months.2-4*
Are there any side effects to be aware of?
As with any medication or prescription injection, there are potential side effects, so it’s important to see a trained and experienced professional. Dr. Mariwalla warns that the injector must place the neuromodulator correctly because the effect on the muscle can create temporary side effects like a lowering of the eyebrow or lowering of the upper eyelid. “While this complication can happen to anyone, it is important to note that these effects are temporary,” she adds.
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea. See the bottom of this article for more important safety information, including Distant Spread of Toxin Effect Boxed Warning.
What makes Dysport different from other neuromodulators?
While there are quite a few neuromodulators available on the market right now, Dysport is set apart by its fast-acting1-3† onset and natural-looking results. Dr. Mariwalla says, “I love Dysport for my patients in their 30s to 50s, who want a smoothed look but not necessarily a taught-like-a-drum appearance.”
Unsurprisingly, real Dysport patients feel the same. A recent study found that 98% of users** said their results looked natural.5‡
The bottom line – smoother frown lines
If you’re looking for a wrinkle-fighter that won’t leave you looking frozen, look no further than Dysport. Book your appointment with an experienced injector today who can discuss all your options and provide you with natural-looking, fast-acting1-3† and long-lasting2-4* results that will help you look and feel more confident than ever5§#.
#Subject-reported at 12 months (N=120) after two treatments six months apart in a phase IV, multicenter, prospective study.
§3 out of 10 FACE-Q questions about psychological function are shown.
†A secondary endpoint based on Kaplan-Meier estimates of cumulative rate of time to onset of response. The median time to onset of response was 3 days in GL-1 (Dysport 55/105 [52%], Placebo 3/53 [6%]) and GL-2 (Dysport 36/71 [51%], Placebo 9/71 [13%]), and 2 days in GL-3 (Dysport 110/200 [55%], Placebo 4/100 [4%]).
*GL-1 and GL-3 evaluated subjects for at least 150 days following treatment. Based on a ≥1-Grade GLSS improvement from baseline utilizing data from two double-blinded, randomized, placebo-controlled pivotal studies (GL-1, GL-3) in a post-hoc analysis.
**Users = clinical trial subjects
‡ Subject’s satisfaction and self perception reported 3 weeks after treatment (n=531).
- Data on file. GL-Y-97-52120-085 (GL-2) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
- Data on file. GL-Y-97-52120-719 (GL-1) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
- Data on file. GL-Y-97-52120-718 (GL-3) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
- Data on file. MA-35497. Post Hoc Analysis. Fort Worth, TX: Galderma Laboratories, L.P., 2017.
- Molina B, Grangier Y, Male B, et al. Patient satisfaction after the treatment of glabellar lines with Botulinum toxin type A (Speywood Unit): a multi-centre, prospective, non-interventional European observational study. J Eur Acad Dermatol Venereol. 2015 (7):1382-1388
Important Safety Information
Dysport® (abobotulinumtoxinA) is a prescription injection for temporary improvement in the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults less than 65 years of age.
What is the most important information you should know about Dysport? Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect areas of the body away from the injection site. Symptoms can happen hours to weeks after injection and may include swallowing and breathing problems, loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there have been reports of death. You are at the highest risk if these problems are pre‐existing before injection.
These effects could make it unsafe for you to drive a car, operate machinery, or do other dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic reaction to any other botulinum toxin product, such as Myobloc®, Botox®, or Xeomin®, have a skin infection at the planned injection site, under 18 years of age, or are pregnant or breastfeeding.
The dose of Dysport is not the same as the dose of any other botulinum toxin product and cannot be compared to the dose of any other product you may have used.
Tell your doctor about any swallowing or breathing difficulties and all your muscle or nerve conditions such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis, or Lambert‐Eaton syndrome, which may increase the risk of serious side effects including difficulty swallowing and difficulty breathing. Serious allergic reactions have occurred with the use of Dysport. Dry eye has also been reported.
Tell your doctor about all of your medical conditions, including if you have surgical changes to your face, very weak muscles in the treatment area, any abnormal facial change, injection site inflammation, droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, wrinkles that can’t be smoothed by spreading them apart, or if you are pregnant or breastfeeding or planning to become pregnant or breastfeed.
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause serious side effects. Do not start any new medicines while taking Dysport without talking to your doctor first.
Especially tell your doctor if you: have received any other botulinum toxin product, such as Myobloc® (rimabotulinumtoxinB), Botox® (onabotulinumtoxinA), or Xeomin® (incobotulinumtoxinA), in the last four months or any in the past (be sure your doctor knows exactly which product you received, have recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take a sleep medicine.
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
Ask your doctor if Dysport is right for you.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
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