This Injectable Can Improve Between-the-Brow Wrinkles in Just 2 to 3 Days

This Injectable Can Improve Between-the-Brow Wrinkles in Just 2 to 3 Days featured image
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The quest for a line-free face often feels like an uphill battle. After all, many of us have been told that a solid skin-care routine is the single best option for maintaining flawless skin, but that can only go so far.

In fact, experts agree that while a good skin-care routine is important for a healthy complexion, injectables—specifically neuromodulators like Dysport(abobotulinumtoxinA)* for the frown lines between the brows—may help with lasting results.1-3‡ (*Please see Full Important Safety Information, including Distant Spread of Toxin Effect Boxed Warning at the end of this article.)

If you’re unfamiliar with this popular wrinkle reducer, don’t fret. Park Avenue’s “artist to the celebrities”, Dr. Anna Avaliani, specializes in cosmetic dermatology and non-invasive laser surgery and breaks down exactly what this injectable does, how it works, and why it’s a good option to include alongside your current routine.

What is Dysport and how does it work to temporarily reduce wrinkles?

Dysport is a prescription injection that works to temporarily reduce muscle activity for the frown lines between the brows, therefore preventing the skin from wrinkling itself when you make facial expressions. “It works by relaxing the muscle movement responsible for creating dynamic wrinkle lines,” explains Dr. Avaliani.

This injectable specifically improves the look of moderate-to-severe frown lines between the eyebrows, also called the glabellar lines or “elevens.” These lines are often responsible for giving us an angry look, so by smoothing them out, people can potentially look both younger and less stressed.

What can patients expect after undergoing a Dysport treatment?

An appointment for Dysport is often rather quick and easy. “The treatment itself can take as little as 10 minutes, and my patients like Dysport because the results are very natural-looking,” says Dr. Avaliani.

The most common side effects of Dysport are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea. See the bottom of this article for more important safety information, including Distant Spread of Toxin Effect Boxed Warning.

After the injections are finished, you’ll likely see results in about two to three days after treatment 2-4† with final results settling around 14 days after treatment that may last up to 5 months.1-3‡ “[You can expect a] soft, natural look without harsh lines or feeling frozen,” affirms Dr. Avaliani.

How does Dysport minimize wrinkles and what role do anti-aging creams play? 

“Lines are caused by muscle expression creating dynamic wrinkles, and factors such as aging and sun damage lead to thinning of skin,” explains Dr. Avaliani. “Muscles are strong, and their constant movement and engagement leads to development of static lines, which only look deeper in thin and sun-damaged skin.”

Ultimately, by using a neuromodulator to help to smooth and minimize facial expressions, new lines may not form and existing lines may not worsen. On the other hand, over-the-counter anti-aging creams typically improve the quality of the skin itself. “Neuromodulators like Dysport improve the look of wrinkles; creams act as a boost to the overall health of the skin,” explains Dr. Avaliani.

For example, rockstar ingredients, like retinoids, improve texture and pigmentation. Other products, like sunscreen, help protect skin from developing skin cancer, while vitamin C serums are essential to help fight free radicals which can damage the structure of collagen. “Dysport can help lead to natural-looking, non-invasive results, and creams can work to benefit your overall complexion.”

The final takeaway

Injectables reign supreme for those in the pursuit of flawless, natural-looking skin. If you’re looking for a wrinkle-fighter that will deliver natural-looking results, Dysport is certainly worth asking about.

With that in mind, it’s still important to practice a good skin-care routine in order to ensure you tackle skin aging from all angles. Just be sure to book your appointment with an experienced injector who can discuss whether this in-office treatment is the best option for you and your aesthetic concerns.

†A secondary endpoint based on Kaplan-Meier estimates of cumulative rate of time to onset of response. The median time to onset of response was 3 days in GL-1 (Dysport 55/105 [52%], Placebo 3/53 [6%]) and GL-2 (Dysport 36/71 [51%], Placebo 9/71 [13%]), and 2 days in GL-3 (Dysport 110/200 [55%], Placebo 4/100 [4%]).

‡GL-1 and GL-3 evaluated subjects for at least 150 days following treatment. Based on a ≥1-Grade GLSS improvement from baseline utilizing data from two double-blinded, randomized, placebo controlled pivotal studies (GL-1, GL-3) in a post-hoc analysis.

  1. Data on file. GL-Y-97-52120-719 (GL-1) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  2. Data on file. GL-Y-97-52120-718 (GL-3) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.
  3. Data on file. MA-35497. Post Hoc Analysis. Fort Worth, TX: Galderma Laboratories, L.P., 2017
  4. Data on file. GL-Y-97-52120-085 (GL-2) Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2007.


Dysport® (abobotulinumtoxinA) is a prescription injection for temporary improvement in the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults less than 65 years of age.

Important Safety Information

What is the most important information you should know about Dysport? Spread of Toxin Effects: In some cases, the efects of Dysport and all botulinum toxin products may affect areas of the body away from the injection site. Symptoms can happen hours to weeks afer injection and may include swallowing and breathing problems, loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there have been reports of death. You are at the highest risk if these problems are pre-existing before injection.

These effects could make it unsafe for you to drive a car, operate machinery, or do other dangerous activities.

Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic reaction to any other botulinum toxin product, such as Myobloc®, Botox®, or Xeomin®, have a skin infection at the planned injection site, under 18 years of age, or are pregnant or breastfeeding.

The dose of Dysport is not the same as the dose of any other botulinum toxin product and cannot be compared to the dose of any other product you may have used.

Tell your doctor about any swallowing or breathing difficulties and all your muscle or nerve conditions such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome, which may increase the risk of serious side effects including difficulty swallowing and difficulty breathing. Serious allergic reactions have occurred with the use of Dysport. Dry eye has also been reported.

Tell your doctor about all of your medical conditions, including if you have surgical changes to your face, very weak muscles in the treatment area, any abnormal facial change, injection site inflammation, droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, wrinkles that can’t be smoothed by spreading them apart, or if you are pregnant or breastfeeding or planning to become pregnant or breastfeed.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause serious side efects. Do not start any new medicines while taking Dysport without talking to your doctor first.

Especially tell your doctor if you: have received any other botulinum toxin product, such as Myobloc® (rimabotulinumtoxinB), Botox® (onabotulinumtoxinA), or Xeomin® (incobotulinumtoxinA), in the last four months or any in the past (be sure your doctor knows exactly which product you received), have recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take a sleep medicine.

Common Side Effects

The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.

Ask your doctor if Dysport is right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. 

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Dysport Full Prescribing Information including Medication Guide at DysportUSA.com.

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