17 Celebs Who’ve Opened Up About Using GLP-1s

Chrissy Metz

Metz spent about six years saying no to GLP-1s before she said yes. The This Is Us actress, 45, told TODAY that she resisted the medication because she doesn't do things simply because her friends are doing them, but changed course after a friend explained the broader health benefits and her doctors signed off. She's now partnered with Ro as a brand ambassador. “No matter what I do, people are going to talk,” she says. Her advice to anyone considering the medication: stay skeptical, do your research and start with a trusted doctor.

Rosie O’Donnell

A type 2 diabetes diagnosis three years ago put the comedian, 64, on Mounjaro. She's since lost about 60 pounds, deliberately slowly, at a pound or two a month. “Mounjaro saved my life,” she told People in a July cover story, describing a lifetime of weight struggle and her surprise at how completely the medication quieted her food noise.

O'Donnell has been pointed about refusing to keep it private. She later revealed she'd had a deep plane facelift to address lower-face laxity after the weight loss—a decision that required her to rethink a long-held stance against plastic surgery.

Trisha Paytas

The Hacks star and podcaster says she's lost 26 pounds in six weeks and told NewBeauty in an exclusive interview that she almost kept it private. With Ro as part of her treatment plan, she says using telehealth is what made her comfortable starting at all.

The biggest surprise while taking the medication, she says, wasn't the number on the scale but the quieted food noise. “I still love food,” she shared. "If anything, one of the biggest surprises has been realizing I can enjoy the foods I love without food taking up so much space in my brain.”

Emily Simpson

The Real Housewives of Orange County star credits a wake-up call, a gym membership and a GLP-1, in that order. Simpson told Us Weekly she started training seven days a week for two hours a day after seeing unflattering set photos ahead of her 50th birthday. “I did take a GLP-1, so I always want to be honest about that,” said the reality star.

Kendra Wilkinson

Wilkinson's first attempt at a GLP-1 lasted exactly one dose, says the former Girls Next Door star. She posted on Instagram in April 2025 that she'd started weight-loss shots—and was throwing them out. In March 2026, she did a 180, sharing with fans that she was being "really intentional" this time while taking a GLP-1, focused less on weight than on energy, transparency and not rushing the process.

Chrissy Teigen

Teigen turned to Ozempic after losing her son Jack at 20 weeks, describing a body that felt frozen in place. “My body was completely stuck,” she said on her podcast, Self-Conscious, explaining she'd gained about 40 pounds during the pregnancy and couldn't lose it—until the medication helped things shift after about a year. She later told People she went public because she wanted followers to see the unglamorous parts too.

Serena Williams

Williams said she turned to a GLP-1 after struggling to lose weight post-pregnancy despite training and eating clean. The tennis legend and WYN Beauty founder revealed she lost more than 31 pounds and that the medication “helped me enhance everything that I was already doing—eating healthy and working out.” She added, “I feel really good and healthy. I feel light physically and light mentally.”

Andy Cohen

On his Radio Andy show, Cohen admitted he “microdosed a GLP-1 all summer” and lost 25 pounds. "It really helped me with cravings, which I was having a very hard time with," he said, adding that it pushed him to be "more disciplined with my diet and with working out."

Dolores Catania

The RHONJ star has been open about using Ozempic and later Mounjaro while navigating menopause and thyroid issues. “When you start the GLP-1s, one of the side effects is nausea,” she shared, noting that staying active was still essential: “You still have to work out...People don't believe that. I have to be pushed to go.”

Meghan Trainor

After her second pregnancy, Trainor told her Instagram followers she leaned on Mounjaro to regain balance in her health routine. “Yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I'm so glad I did because I feel great.” She added: “I've been on a journey to be the healthiest, strongest version of myself for my kids and for me.”

Amy Schumer

Although the comedian previously shared that she tried a GLP-1 but couldn't tolerate the side effects, Schumer later told social media followers that she connected with Midi Health—a company she's also invested in—to help treat her perimenopause symptoms. She said she was prescribed estrogen and progesterone and added that Mounjaro has been “great.”

Since then, Schumer has shared her weight loss and removed some older, pre–weight-loss photos from Instagram, explaining that her focus has been on feeling better physically. “I have been working to be pain-free and I finally am,” she wrote in a since-deleted post, adding that her endometriosis has improved, her back is healing and she no longer has Cushing syndrome.

Whoopi Goldberg

On The View, Goldberg explained she weighed nearly 300 pounds when filming Till and turned to Mounjaro for help. “One of the things that's helped me drop the weight was the Mounjaro. That's what I used,” she said. “I've lost almost two people...it's been really good for me.”

Oprah Winfrey

The TV host and Weight Watchers spokesperson has always been open about her weight loss journey, and she revealed in 2023 that she added weight-management medication to her health plan. “Obesity is a disease. It's not about willpower, it's about the brain,” she said. Calling it “a gift, not something to hide behind,” she explained, “I now use it as I feel I need it, as a tool to manage not yo-yoing.”

Vanessa Williams

In an interview with Hello! Magazine, Williams revealed she's been taking Mounjaro for the past two years, calling it a “game-changer"“for navigating menopausal weight gain. After turning 60, she wanted to feel like herself again and “look my best,” especially as her body began changing in ways that felt out of her control despite maintaining the same routine. She also said she started hormone replacement therapy and NAD+ injections, telling the outlet, “Science is amazing.”

Kelly Clarkson

Clarkson clarified that while she is not on Ozempic, she began another prescription after her bloodwork worsened. “Everybody thinks it’s Ozempic, but it’s not. It’s something else,” she said. “Mine is a different [drug] than people assume, but I ended up having to do that too because my bloodwork got so bad.”

Rebel Wilson

Wilson revealed she briefly tried Ozempic after her fertility doctor suggested it. “Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good,” she told The Sunday Times. Five years after losing 80 pounds, she's been candid about slipping back during new motherhood and heavy work stretches. “It took a lot to remind myself that these fluctuations are normal,” she says. Now in her second year as Noom's chief wellness ambassador, she launched the "Lose for Keeps" campaign.

Jonathan Van Ness

The Queer Eye star has been candid about his use of a GLP-1 to manage a binge-eating disorder. “Alright, I have a confession to make. Yes, I am on a GLP-1 for a weight-loss medication,” he told People. He later shared that he’d lost 66 pounds, crediting the medication along with a healthier diet and Pilates: “My mental health and overall feeling is a different universe since last year.”