The power of neurotoxins is not lost on women over 50 or the doctors who administer them. “Neurotoxins have helped both men and women fight off that aging look, and we all know when we look better, we feel better,” says Delray Beach, FL dermatologist Dr. Janet Allenby. With a handful of different neurotoxins to choose from, you might find yourself wondering which is best for addressing the changes that come with aging and menopause.
While there’s not one overarching neurotoxin that experts consider to be the best for mature skin, there are nuances that make some more appealing for different reasons. “When it comes to neurotoxins, I can’t say that one is much better than the other for addressing women who are hormonally challenged,” says Dr. Allenby. “I would say each neurotoxin has its own characteristics, and each person has their own specific needs, regardless of their hormone status, and that’s how we should choose their neurotoxin.”
New York dermatologist Jody Levine, MD notes that the decision of which neurotoxins to use should have “less to do with the type of skin or age of skin and more to do with the patient's anatomy, timing needs with regard to onset and duration, and the consideration of antibody formation.” To get a better understanding of the nuances we asked experts which neurotoxins they tend to turn to most often for treating menopausal skin, and what makes them a good go-to.
Featured experts
- Dr. Janet Allenby is a board-certified dermatologist in Delray Beach, FL
- Jody Levine, MD is a board-certified dermatologist in New York
- Marina Peredo, MD is a board-certified dermatologist in New York
The benefits of Daxxify for menopausal skin
To New York dermatologist Marina Peredo, MD, Daxxify stands out as the most effective for improving skin quality concerns, like texture, radiance and longevity, which makes it especially well-suited for menopausal skin. Dr. Peredo notes Daxxify’s fast onset of visible smoothing is also a plus. Additionally, Daxxify tends to last longer than some of the other neurotoxins, says Dr. Levine, “so if it's hard for a patient to come in every three months and they need a product that lasts longer than the others, I will recommend Daxxify."
“What sets Daxxify apart for skin appearance is the peptide-powered formulation (PXT), which plays a crucial role in its performance. This proprietary stabilizing peptide helps the botulinum toxin diffuse more evenly, enhancing its ability to smooth fine lines and contribute to the ‘bouncy,’ luminous skin quality patients often report,” says Dr. Peredo. “Many of my post-menopausal patients and clinic staff have described a distinctive ‘Daxxify glow’—a brighter, smoother complexion that was not achieved with previous treatments using other neurotoxins.”
Ultimately, Daxxify is a good option for those looking to address not only dynamic wrinkles but also skin quality, says Dr. Peredo. “Its peptide-based formula, rapid onset, and ability to deliver a visible glow make it a strong choice for patients seeking more than just wrinkle reduction—especially those navigating the hormonal shifts and structural changes that occur with age.”
The benefits of Botox Cosmetic for menopausal skin
As the most commonly recognized household name, Botox Cosmetic tends to get a lot of attention, which can sometimes help a patient feel more comfortable going in. “Botox has been around the longest, so if someone feels more confident using that product, then I will choose it,” says Dr. Levine. The decades of studies help put patients at ease, and doctors know they can trust it.
The benefits of Dysport for menopausal skin
Dysport is known for spreading wider than the other neurotoxins, which makes it appealing for use on mature women. “Often in a menopausal woman with many wrinkles on her forehead, or longer wrinkles along the forehead, I may choose to use Dysport because of its spread,” says Dr. Levine.
The benefits of Xeomin for menopausal skin
Xeomin could be a good option for someone who has been getting neurotoxin injections for years. Xeomin contains only pure botulinum toxin type A, without any accessory proteins. “Theoretically, if one has been using a neurotoxin for many years and has developed antibodies to the proteins that accompany it, they are better off using Xeomin,” says Dr. Levine. “Theoretically, one is less likely to make antibodies to Xeomin than to the other products.”
