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Getting to the Root of Hair Loss: Injectable Treatment for Maximum Hair Regrowth

Getting to the Root of Hair Loss: Injectable Treatment for Maximum Hair Regrowth featured image
Sergii Kolesnikov / Getty Images

When it comes to treating hair loss, the next big thing is already here. Thanks to pioneering clinical research from dermatologists, and the development of customized formulations at dermatology specialist Chemistry Rx, hair-loss injectables have been identified as a promising method of hair restoration. These injectables may even work in patients who did not respond well to topical and oral treatments alone. An intradermal application of proven hair-loss treatments like minoxidil or dutasteride, hair-loss injectables are a novel in-office hair-restoration therapy that may show signs of regrowth within just a few weeks.

The Clinical Results

Intradermal injections aren’t new. Also referred to as mesotherapy, clinical researchers have been reporting on the effectiveness of this method for skin rejuvenation for several years1. But now, we also have the clinical evidence to show hair-loss injectables are a viable and effective method of hair restoration2,3,4.

Before
After*

Pictures courtesy of Dr. Carlos Wambier.

(*Three once-monthly sessions with minoxidil + dutasteride injectables. Photos demonstrate substantial increase in hair density four months after starting therapy.)

“Our clinical study2 evaluated hair regrowth after minoxidil and dutasteride intradermal drug delivery in men with androgenetic alopecia,” explains Carlos Wambier, MD, director of clinical trials at the Department of Dermatology at Brown University and South Kingstown, RI dermatologist. “Most patients experienced significant hair growth.”

Dr. Wambier further explains: “With two sessions we already perceive the regrowth, and it continues to increase with more sessions.” Mesotherapy can be performed with syringes, microneedling or even a tattoo machine. “Usually, one procedure takes from 15 to 30 minutes. The learning curve is much easier with syringes since most providers are used to injecting intralesional triamcinolone into the scalp,” Dr. Wambier says.

What Doctors Have to Say

Before
After*

Pictures courtesy of Dr. Carlos Wambier.

(*Two once-monthly sessions with minoxidil + dutasteride injectables. Photos demonstrate substantial increase in hair density three months after starting therapy.)

Hair-loss injectables have the potential to appeal to patients for a multitude of reasons, and patients may also be seeing better results than with topical or oral treatments alone.

“The dutasteride pill may have side effects that are real and can linger even after stopping; the topical can be messy to apply and thus compliance can suffer,” explains New York dermatologist Robert Finney, MD.

Dr. Finney also says: “Mesotherapy is well tolerated, with no reported sexual side effects and you can potentially get a great result with only four treatments yearly. More importantly, it is much more effective than topical treatments.”

The first several treatments are often administered once monthly, to maximally stimulate hair growth. After the initial phase, mesotherapy is spaced out over a few months, with at least one treatment recommended per season.

New York dermatologist Angela Lamb, MD explains that she frequently uses two treatment modalities in one patient to provide an extra boost: mesotherapy with Chemistry Rx hair-loss injectables and platelet-rich plasma (PRP). “When we’re combining it with treatments like minoxidil and dutasteride, we’re giving it a boost of growth factors right around the follicle. That helps the hair grow fuller, faster and longer,” Dr. Lamb says.

For Dr. Finney, mesotherapy also presents the answer to an often discussed problem with oral dutasteride: a decrease in sexual libido. Dr Finney says: “Although quoted rates of sexual side effects to orals in the literature are always very low, in real life I encounter them regularly. Many men are embarrassed to report it, especially if they are only noticing a mild effect on their libido.”

This is another area where hair-loss injectables shine: “Either way, efficacy of topicals is not equivalent to the oral medications. Injectables bridge that gap. It is more effective than the topical form but lacks the side effects of the oral form. There are no reported sexual side effects from dutasteride mesotherapy in any of the trials, nor in myself or any patient I have performed the injections on,” Dr. Finney explains.

Who Makes a Good Candidate?

“Anyone with hair loss is a good candidate,” says Dr. Finney. Clinical evidence shows that hair-loss injectables with dutasteride and minoxidil can successfully grow hair in both women and men, regardless of skin tone and hair type 2,3,4.

Hairloss injectables come as a dutasteride formulation and a minoxidil formulation. Each can be administered alone, or the two injectables can be mixed with each other before injection. Even minoxidil hair-loss injectable alone can make a difference5. Dr. Finney explains: “Minoxidil helps to regrow hair via a completely different path, so only increases our chances of success.”

Additionally, customized hair loss injectables by Chemistry Rx may serve as an excellent option not only for anyone who is experiencing negative side effects from taking oral dutasteride, but also from taking oral or topical minoxidil.

“Some of the side effects of oral medications are not tolerated by women,” Dr. Lamb explains. “Taking minoxidil orally, for example, can lead to hair growth on the face. And in my male patients, that isn’t a problem. But in my female patients growing a moustache or beard, that’s a bigger issue.”

One Tool of Many

Everyone wants their care to be customized and personalized. Chemistry Rx specializes in customized treatments for medical and cosmetic dermatology, formulating an extensive array of groundbreaking topical and oral formulations that are prescribed to address a diverse range of conditions. These formulations, all hand-designed by Clinical and Scientific Director Dr. Lars Brichta, provide comprehensive, personalized care that considers patients’ individual needs. Thus, many patients can reap the rewards of such tailored treatment options.

Hair loss is no different. Through years of working with the top physician innovators in this field, Chemistry Rx is able to offer hundreds of customized topical and oral formulations, in addition to the injectables. These highly customized medications can fit each patient’s unique hair restoration journey.

“Combination therapy is always the most successful,” says Dr. Finney. Still – customized formulations such as hair-loss injectables are not always made the same way. Dr. Finney elaborates: “The most important thing that determines safety is the formulation. Sometimes different pharmacies may use different inactive ingredients.”

Certain inactive ingredients, however, can have a negative impact on hair6.

“Some of these, such as ethanol, have been reported to trigger hair loss that in some cases was permanent.” Dr. Finney adds: “I did a lot of research prior to offering this in my clinic and I found that the formulation by Chemistry Rx was pure and lacked undesired inactive ingredients. My results have been great and because of the purity, I have not had any side effects.”

As a powerful and innovative novel tool in your practice, sterile formulations of minoxidil and dutasteride hair-loss injectables by Chemistry Rx have the potential to provide patients a strong pathway to hair restoration. Combined with other treatments, crafted with care specifically for your patient’s needs, hair-loss injectables are a sign that the future is now.


References

  1. Iranmesh B. et al. Employing hyaluronic acid-based mesotherapy for facial rejuvenation. J Cosmet Dermatol. 2022 Dec;21(12):6605-6618.
  2. Ragi S.D. et al. Evaluation of hair regrowth after minoxidil and dutasteride tattooing in men with androgenetic alopecia. JAAD Int. 2023 May 20;12:103-104.
  3. Saceda-Corralo D. Mesotherapy With Dutasteride for Androgenetic Alopecia: A Retrospective Study in Real Clinical Practice. J Drugs Dermatol. 2022 Jul 1;21(7):742-747.
  4. Moftah N. et al. Mesotherapy using dutasteride-containing preparation in treatment of female pattern hair loss: photographic, morphometric and ultrustructural evaluation. J Eur Acad Dermatol Venereol. 2013 Jun;27(6):686-93.
  5. Uzel B.P.C. et al. Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: A randomized, placebo-controlled trial. Dermatol Ther. 2021 Jan;34(1):e14622.
  6. Reguero Del Cura L. et al. Two Cases of Paradoxical Nonscarring Alopecia after Mesotherapy with Dutasteride. Skin Appendage Disord. 2022 Jan;8(1):46-48.

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