The 10 Best-Selling Serums at Dermstore Right Now

10. Obagi Professional-C Serum 15 ($102)

A professional-grade vitamin C serum that revs up collagen and elastin growth, brightens skin and hydrates? Yes, please.

9. iS Clinical Active Serum ($135)

Perhaps the most multitasking serum of the bunch, this one combats redness, acne, signs of aging, free-radical damage, fine lines and overall laxity. The best part: all skin types play well with its superlight formula.

8. SkinCeuticals Phloretin CF ($166)

Antioxidants and vitamins C and E go to town on hyperpigmentation and dark spots in this daytime-only formula that layers perfectly under makeup as it fights off damaging free radicals. 

7. SkinCeuticals Phyto Corrective Gel ($67)

Have irritated, sensitive skin that can’t catch a break? This picture-perfect serum is for you. Packed with soothing herbal extracts and moisturizing hyaluronic acid, every application works to calm exasperated skin and nurse it back to health.

6. SkinCeuticals Blemish Age Defense ($92)

A personal favorite, this gentle-yet-powerful formula boasts the acne-busting trifecta: glycolic acid, salicylic acid and AHAs—all without leaving any weight on my already-oily skin.

5. SkinMedica TNS Essential Serum ($281)

Named an absolute must-have for countless skin experts we’ve interviewed over the years, this do-everything dual-formula proves tough on stubborn wrinkles and overall aged-looking skin thanks to its superstar ingredient list. On it: vitamin E, hyaluronic acid, peptides, antioxidants and vitamin C.

4. SkinCeuticals Hydrating B5 Gel ($83)

Is your skin in need some serious hydration? Glow-boosting hyaluronic acid and tissue-repairing vitamin B5 merge in this light-as-water serum that boosts the results of your regular moisturizer for a double dose of hydration.

3. SkinCeuticals Hyaluronic Acid Intensifier ($100)

Essentially plumper skin in a bottle, this HA-powered serum amplifies skin’s hyaluronic acid levels by 30 percent, no matter your skin type. Smooth it on your crow’s feet or nasolabial folds and watch its plumping magic for yourself.

2. Obagi Professional-C Serum 20 ($127)

You get what you pay for, right? Case in point: this potent serum, which boasts a cocktail of 20-percent L-ascorbic acid and hyaluronic acid designed to penetrate skin deeper than similar serums.

1. SkinCeuticals CE Ferulic ($166)

Did we really think anything other than this derm-beloved product would take the top spot? Its blend of vitamins C and E and ferulic acid has garnered more than 1,700 five-star reviews on this retailer alone. If you haven’t tried it, it might be time.