When it comes to anti-aging skin care, NewBeauty readers over 40 are seeking serious results—especially when it comes to smoothing lines, firming texture and reviving dull skin. According to a recent survey of more than 1,300 readers,* there’s one serum that stands out from the rest, and it combines eight steps into a single one. DefenAge 8-in-1 BioSerum ($198) has become a trusted go-to for delivering visible skin rejuvenation, whether used alone or layered with retinol.
Dermatologist-recommended, this multitasking serum is powered by DefenAge’s proprietary Age-Repair Defensin Complex and offers the cumulative benefits of eight different serums in a single formula—everything from antioxidants and peptides to DNA-repair enzymes and retinol alternatives.
For 64-year-old users, it’s a mainstay and a must-share: “It is always in my arsenal. I gift this product as well to my best friend, my sister and my Pilates instructor.”
Readers in their 30s and 40s also praised its ability to improve skin tone and complement more intensive actives like retinol. A 38-year-old shared: “The bioserum has greatly improved the look of my skin. My skin looks younger and my melasma is significantly better.” And a 46-year-old shared it “Works well with retinol” and “helps with lines.”
The Science Behind the Serum
The reason this serum has earned a cult-like following is its comprehensive formula. Designed to replace multiple products in a single step, DefenAge 8-in-1 BioSerum combines eight powerful types of treatment serums into one concentrated solution. Inside the bottle: antioxidants, tone-evening niacinamide, hyaluronic acid, collagen, calming anti-inflammatories, peptides, a retinol alternative and a DNA-repairing enzyme.
Each component is designed to target a key aging concern—hydration, texture, tone, firmness and more—making this multitasking serum a smart choice for anyone looking to simplify their routine without sacrificing serious clock-reversing results.
*Source: BeautyEngine Advanced Research, 2025
