The Best Peptide Eye Creams to Firm and Plump Tired Eyes

If your eye cream isn’t multitasking, it might be time to upgrade. Peptides—short chains of amino acids that help stimulate collagen production and deliver a plumping effect—are the secret sauce behind some of the most effective formulas on the market. Whether you’re dealing with dark circles, puffiness, dryness or fine lines, these peptide-packed eye creams do the most when it comes to rejuvenating tired eyes.

1 / 10

iNNBEAUTY PROJECT Extreme Cream Eye Firming & Contouring Refillable Eye Cream ($48)

Designed to visibly lift and firm loose skin around the eyes and lids, this refillable formula goes beyond hydration and is clinically proven to reduce the length, depth and width of wrinkles.

• BUY ON INNBEAUTY PROJECT – $48
• BUY ON SEPHORA – $48

2 / 10

Dieux Auracle Peptide & Antioxidant Eye Gel ($44)

Fragrance-free and sensitive-skin friendly, this gel combines peptides with antioxidants to plump, hydrate and smooth. It wears well under makeup and offers a weightless feel, making it an easy everyday essential.

• BUY ON DIEUX – $44
• BUY ON SEPHORA – $44

3 / 10

U Beauty The RETURN Eye Concentrate ($148)

Designed to tackle lines, puffiness and dark circles, this luxe plumping and brightening cream helps turn back the clock on all signs of aging eyes.

• BUY ON U BEAUTY – $148
• BUY ON AMAZON – $148

4 / 10

Peter Thomas Roth Peptide Skinjection Fill + Fix Under-Eye Cream ($45)

Infused with peptides and hyaluronic acid, this cream instantly boosts the appearance of volume and smooths fine lines, especially in hollow under-eye areas.

• BUY ON SEPHORA – $45
• BUY ON ULTA – $45

5 / 10

BYOMA Barrier+ Eye Cream ($15)

This barrier-repairing cream is packed with antioxidants and peptides that soothe and plump while reinforcing the skin’s natural defenses around the delicate eye area.

• BUY NOW – $15

6 / 10

Caudalie Resveratrol-Lift Depuffing Eye Cream with Peptides ($65)

Powered by resveratrol, vegan collagen and peptides, this gel-cream helps firm, depuff and smooth. The cooling tip adds an instant pick-me-up, especially in the mornings.

• BUY ON SEPHORA – $65
• BUY ON AMAZON – $65

7 / 10

Naturium Multi-Peptide Eye Cream ($16)

This silky, lightweight cream offers an impressive blend of peptides that target the look of fine lines and wrinkles without feeling heavy. Bonus: it layers beautifully with makeup.

• BUY ON AMAZON – $16
• BUY ON ULTA – $16

8 / 10

Summer Fridays Light Aura Vitamin C + Peptide Eye Cream ($44)

This brightening formula combines vitamin C, caffeine and peptides to hydrate, firm and depuff while adding a subtle luminosity that makes eyes look instantly more awake.

• BUY ON SEPHORA – $44
• BUY ON AMAZON – $44

9 / 10

Dr. Dennis Gross Skincare DermInfusions Fill + Repair Eye Cream ($64)

This super-hydrating eye cream targets six zones—crow’s feet, under eyes, lids, bunny lines, elevens, and the inner tear trough—for firmer, younger-looking eyes from every angle.

• BUY ON DERMSTORE – $64
• BUY ON REVOLVE – $64

10 / 10

belif Moisturizing Eye Bomb with Peptide and Ceramide ($48)

If dryness is your main concern, this is your fix. With peptides, ceramides, squalane and caffeine, it delivers up to 48 hours of hydration while visibly plumping and smoothing tired eyes.

• BUY ON SEPHORA – $48
• BUY ON ULTA – $48