The 21 Best Serums for Skin Over 50

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The 21 Best Serums for Skin Over 50 featured image

Serums are essential to skin health—as a bonus, they also afford one of the most sensorial moments of a skin-care routine. The serums you used in your 20s, likely for hydration or dialed-up dewiness, may not necessarily be the best serums for you in your 50s. There are many serums that target signs of aging, from wrinkles to moisture loss, that are perfectly formulated to help rejuvenate skin. We’ve curated a list of the best serums for skin over 50.

1 / 21

SkinMedica TNS Advanced+ Serum ($295)

Fine lines, deep wrinkles and sagging skin are no match for this powerful potion. It works by encouraging skin cell renewal and supporting collagen and elastin levels for an all-around more youthful appearance.

2 / 21

Paula’s Choice Phytoestrogen Elasticity Renewal Serum ($48)

Bring back the youthful bounce in your skin with this elasticity-restoring serum. It’s formulated to visibly improve signs of aging that coincide with estrogen decline.

3 / 21

RéVive Intensité Volumizing Serum Ultime Targeted Skin Filler ($600)

Yes, this product is a splurge, but it’s important to note that it’s meant specifically for the tiny creases on your face, not to liberally slather from cheek to cheek. The advanced volumizing technology helps fill in wrinkles by plumping, smoothing and restoring volume. It’s perfect for visible furrow lines, nasal labial creases, crow’s feet and other wrinkle-prone areas.

4 / 21

Charlotte’s Magic Serum Crystal Elixir ($80)

This serum boasts both immediate effects and long-lasting results. A clinical study found that, in eight weeks, skin appears more elastic by 122 percent and firmer by 49 percent. In that same amount of time, the appearance of wrinkles is visibly reduced by 34 percent and pores by 39 percent.

5 / 21

BL+ The Serum ($180)

Not only will this serum target signs of aging it will also optimize skin health over time. The actives in this formula help hydrate, promote collagen production, prevent UV-induced collagen degradation, combat environmental aggressors and reduce free radical damage, which will contribute to a healthier, younger-looking complexion.

6 / 21

Trinny London Plump Up Peptide+ HA Serum ($90)

The advanced peptides in this serum help champion skin’s collagen and elastin production for a plumper complexion with reduced fine lines. The hyaluronic acid quenches parched skin, which helps restore a bit of bounce.

7 / 21

Stripes The Power Move ($85)

This serum from Naomi Watt’s new line is formulated specifically for (peri)menopausal skin. Five different versions of hyaluronic acid and the star ingredient, ectoine, firm, hydrate and plump skin for a smoother, more radiant complexion.

8 / 21

L’Oréal Age Perfect Cell Renewal Midnight Hydrating Serum ($44)

Say hello to new cells with this drugstore serum. They report that after one use skin feels refreshed and firmer, and within one week, skin appears brighter and younger.

9 / 21

Eve Lom Radiance Repair Retinol Serum ($185)

Gentle yet potent, this sophisticated formula features wrinkle-fighting liposome encapsulated retinol and microbiome re-balancing prebiotic oat kernel ferment to fend off signs of aging without irritation. It delivers a firmer, smoother, more even complexion without the usual tricky side effects of retinol.

10 / 21

Clinique Smart Clinical Repair Wrinkle Correcting Serum ($99)

This serum is part of Clinique’s most advanced anti-aging line. Scientists and dermatologists helped design the formula, which features peptides, retinoids and hyaluronic acid. Clinique studies found the serum to be as effective as one laser treatment on the look of lines and wrinkles after 16 weeks—need we say more?

11 / 21

Biossance Squalane + Copper Peptide Rapid Plumping Serum ($68)

If lackluster skin is one of the biggest indicators of aging for you, you need this plumping serum. It immediately hydrates and noticeably improves firmness and elasticity in one week. In four weeks, 100 percent of people said it reduced the look of fine lines and wrinkles.

12 / 21

SkinCeuticals CE Ferulic ($169)

This cult-classic standby is great for many things, from brightening skin to protecting against environmental aggressors. However, its most beloved benefits include improving signs of aging like fine lines, wrinkles and laxity.

13 / 21

True Botanicals Chebula Active Serum ($90)

Among the top-performing anti-aging serums at a fraction of the price, this True Botanicals product is a keeper, and an Olivia Wilde favorite. If you want softer, smoother skin and a reduced appearance of wrinkles in just weeks, grab this bottle.

14 / 21

Clinical Skin PolyPeptide Firming Serum ($250)

This NewBeauty Award winner employs antioxidants, ceramides, hyaluronic acid and peptides to tackle signs of aging. It promises to make skin feel firmer and look smoother, and it delivers.

Award Photo: PolyPeptide Firming Serum
Award Photo: PolyPeptide Firming Serum
15 / 21

Maya Chia The Super Lift Vitamin C-More Treatment ($110)

For both a quick fix and long-term benefits, Maya Chia’s serum is a great investment. Packed with vitamin C, tranexamic acid, ferulic acid esters, niacinamide, peptides and stem cells, this formula has the ability to brighten skin while also reducing signs of aging.

16 / 21

Valmont V-Line Lifting Concentrate ($290)

This anti-wrinkle and fine line serum does it all. It protects skin from free radicals, tightens and regenerates tissue and reduces wrinkles in the long-term for an all-around more youthful appearance.

17 / 21

OBAGI Medical ELASTIderm Facial Serum ($198)

The unique Bi-Mineral Contour Complex in this formula helps support skin elasticity to help it bounce back from signs of aging more easily. Skin soaks up this fast-acting serum leaving you feeling better just moments after application.

18 / 21

La Prairie Skin Caviar Liquid Lift ($750)

This potent firming serum provides both an immediate lifting sensation and a more lifted appearance over time with continued use. It enhances skin’s firmness, elasticity and volume by helping to restore skin density. You’ll also notice fine lines and wrinkles are visibly reduced after use.

19 / 21

Dieux Skin Deliverance ($69)

A perfect soothing serum for those with aging skin that’s also dry and irritated. Utilizing cannabinoids, niacinamide and other calming ingredients, this formula will even out tone, smooth skin and reduce irritation.

20 / 21

Eminence Firm Skin Acai Booster-Serum ($64)

Superfruit acai is not only good for your body, but it’s also great for your skin. Reviewers note fast and noticeable changes in their skin after using this serum, including reduced signs of aging and smoother, more hydrated, plumper, revitalized skin.

21 / 21

Epionce Intense Defense Anti-Aging and Repair Serum ($150)

Unique ingredients like Spanish needle, melon fruit extract, shiitake mushroom and flax extract give this serum an edge. It goes to work on signs of aging while also helping repair the skin barrier.

Award Photo: Intense Defense Serum
Award Photo: Intense Defense Serum

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