Juvederm and Restylane are very similar. Perlane is a thicker form of Restylane that tends to last a little longer and is placed a little deeper. These products are all hyaluronic acids and add volume to areas of the face. They are used off-label all over the face, including the cheeks, hollow temples, lower eyelids, lips, chin, jowels, etc. They are FDA approved to fill in the nasolabial folds, the lines from the nose to the face (or parenthesis as they are sometimes called). Restylane is also FDA approved for lip augmentation. They work great in VERY, VERY, VERY small doses around the eyes. I like them a lot because they naturally dissolve, are very well tolerated, and if there is an issue, can be dissolved immediately with a product call hyaluronidase. Radiesse is a little different. It is a product composed of calcium-based microspheres and gel that is placed deep and is used as a scaffold to build your own collagen. It is great for shaping the face, especially the mid-face. It does not go near the eyes or in the lips.