It depends on what you are trying to accomplish. Hyaluronics can be used all over, but last a shorter period of time, six to eight months. They work superficial lines and wrinkles better. Radiesse lasts over a year. It’s designed to be more supportive because it’s made form bone particles. Sculptra also is long-term. It lasts two to three years. It helps the body create its own natural collegen, but you need two to three sessions.