I like a small amount of Botox, Dysport or Xeomin to relax the muscles around the mouth. I also like to use a firming cream to help stiffen the skin. In many of my patients, I will customize a filler (many of them are too thick for the thin skin of this area) by adding some saline or lidocaine to thin it out. I will then inject it to reduce the lines. Finally, patients with these lines can benefit from ablative (CO2) laser.