Botox Effects Are Far-Reaching

Botox (Botulinum neurotoxin Type A) has lasting effects on muscles far away from the injection site, says a new study from Massachusetts General Hospital in Boston that was published in the journal Anesthesia & Analgesia.

When the scientists injected Botox into the hind legs of mice, the immediate muscles were completely paralyzed for four days, as expected. The surprising result was the effect on the other hind leg that wasn't injected. It had a lower twitch response to electric stimulation. Sixteen days later, both muscles continued to show weakened function.

While Botox is commonly used to ease wrinkles and the effects of aging on the face, scientists have continued to study its ability to work in other medical ways, such as relieving migraine headaches. Researchers suspect that this latest discovery could have an impact in prepping patients for surgery and helping their surgeons manage their patients' muscle reactions.

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3 Comments
  • Anonymous
    Posted on

    I just got botox for my migraines about a week and a half ago. It consisted of 30 shots. It is supposed to block the nerves that cause the headache. It was painful and I have had cosmetic injections and I don't think they hurt. My insurance company paid for this treatment but I have been diagnosed with chronic migraines which means 3-4 times a week and they last four or more hours. So far I have not noticed a difference but the doctor said it can take up to two weeks to take effect.

  • Devra Wathen
    Posted on

    Can someone explain how migraines can be helped by Botox? Sometimes it feels like they start at the base of my neck and other times the forehead or temple area-so with so many different sites how would they know where to inject? I suffer from migraines at least 5 or more times a month. It seems to be worse when the vog is up in Hawaii. Much Aloha Devra

  • Anonymous
    Posted on

    I wouldn't read too much into this study, as it is likely that the effect was related to an adaptive response since both leg muscles share the same nerve control pathways (NOT Botox moving from one leg to the other). We do see a rebalancing of muscles of expression in the face with Botox however, and expert injectors are able to take advantage of that.

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