How Some of the Latest FDA-Approved Fillers Give You a More Natural Look

Photo Credits: Adobe Stock | Model Used for Illustrative Purpose Only

Whether it’s trying to achieve a tousled, bedhead wave or the perfect no-makeup makeup application, the concept of creating a natural (but better) beauty look is widely appealing. But, as anyone who has attempted to create it will quickly discover, it’s much harder than it sounds. The same is true of some of the most popular anti-aging procedures out there: Neuromodulators and fillers can do wonders helping to fight some of the most common signs of aging, but getting the results to look natural—and not overdone—is not always so easy to achieve.

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Luckily, consumers now have two FDA-approved filler options on the market, and these launches were created with the purpose of providing patients with more natural-looking results. Restylane® Refyne and Restylane® Defyne are two hyaluronic acid dermal fillers that soften and smooth laugh lines (nasolabial folds and marionette lines) and contain next-generation technology to prevent the face from looking fake, injected or stiff. How does it work? We delve into the technology below.

The fillers move with your facial expressions.

Our faces are constantly moving and emoting, whether you realize it or not, so when one part of your face doesn’t, that’s when things start to look unnatural. Restylane Refyne and Restylane Defyne incorporate a unique XpresHAn Technology™, which gives the hyaluronic acid fillers flexibility1 to move within the face as natural expressions are made. XpresHAn Technology™ is made with a special manufacturing process that customizes the degree of hyaluronic acid cross-linking in each product, resulting in smooth gels with a range of flexibility and support that’s tailorable to different patient needs. 

Two different options mean the injectable can be customized to support different needs.

Not everyone needs the same level of support from a filler, and even on the same person, different areas may better treated with different fillers. These fillers from Restylane® give doctors and patients a choice of what to use and where, for results that look more natural. Restylane Refyne is designed to be very subtle and flexible1 for patients who have moderate to severe facial wrinkles and folds2, and Restylane Defyne is designed to provide more support for people with deeper facial wrinkles and folds3. Both fillers are the only ones on the market that have been shown in a clinical trial to help maintain movement and expressions4


1. Data on file. MA-32418 Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2016.
2. Restylane Refyne. Instructions for Use. Fort Worth, TX: Galderma Laboratories, L.P., 2016.
3. Restylane Defyne. Instructions for Use. Fort Worth, TX: Galderma Laboratories, L.P., 2016.
4. Data on file. 05DF1502 Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2016.

Important Safety Information
Approved Uses:
Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.
Restylane® Defyne is indicated for injection into the mid-to-deep dermis for correction of moderate to severe, deep facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.
Restylane Refyne and Restylane Defyne contain traces of gram-positive bacterial protein and are contraindicated for patients with allergies to such material or for patients with severe allergies that have required in-hospital treatment. They should not be used by patients with bleeding disorders, with hypersensitivity to amide-type local anesthetics, such as lidocaine, or by women who are pregnant or breastfeeding.
Possible Side Effects:
The most commonly observed side effects include swelling, redness, pain, bruising, tenderness, headache, lump formation, and itching at the injection site. Use at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete.
These products should not be injected into the blood vessels as they may cause vascular occlusion, infarction, or embolic phenomena. Use with caution in patients recently treated with anticoagulant or platelet inhibitors to avoid bleeding and bruising.
As with all skin injection procedures, there is a risk of infection.
To report a side effect with any of the Restylane products, please call Galderma Laboratories, L.P at 1-855-425-8722.
Restylane Refyne and Restylane Defyne are available only through a licensed practitioner.
Complete Instructions for Use are available at
© 2017 Galderma Laboratories, L.P.
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