What once sounded like a fantasy, could soon be a reality.
ABC reports that a Northern California company, Revance Therapeutics, is already in Phase 3 trials, testing a topical method for administering botulinum toxin for the treatment of crow’s-feet. Its gel formula allows the ingredient to travel through the skin using peptides to deliver the wrinkle-smoothing benefits. Not only do the before-and-after photos look very convincing, but so far, the study shows results lasting twice as long as the three month period that neuromodulators such as Botox, Dysport and Xeomin provide.
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Phase 2 trials of this drug showed that at four weeks, 88.9 percent of subjects achieved clinically relevant improvement in crow’s-feet lines.
“Botox-type gels are here,” says West Palm Beach, FL, dermatologist Kenneth R. Beer, MD. “There are two companies, Revance and Anterios (which was just acquired by Allergan), that have them. I was an investigator for Anterios, and in my opinion, they work. They’re not as good as injections because it’s harder to get something through the skin in large amounts with a gel or cream, but they do work.”
New York dermatologist Francesca Fusco, MD, adds, “I am looking forward to using the new ‘topical-tox.’ It’s only been tested on crow’s-feet so far, and I have many patients with fine crow’s-feet around their eyes who want a natural look, without swelling, bruising or a frozen look. Since it is topical, the risk of a droop or migration to a deeper muscle is minimized.”
A spokesperson for Revance tells NewBeauty that the company plans to commercialize the product and seek approval for the topical treatment for crow’s feet by 2019.
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