The biggest difference is what they are made of. Restylane, Perlane, Juvéderm, and Belotero are hyaluronic acids or sugar-derived molecules. They are all clear and gel-based. Juvéderm tends to be smoother and great for thin skin and for filling superficial lines. Restylane and Perlane are more particulate and firmer so are better for injectable facelifts and sculpting. To lift up the mid-face, or if there are deeper lines, we use a thicker product like Radiesse. Radiesse is a calcium-based filler, that is white and thicker. Because of its color and thickness, it needs to be placed deeper in the skin. It’s not intended for use in the lips or under the eyes. Any of the hyaluronic acids can be digested, so that if you get a lump or a bump, it’s easy to fix. Radiesse is harder to get rid of, but the flip side is that it lasts longer and has a lot more lifting capability.
Restylane is great for first-time users. I use it in lines with superficial to moderate depth (like marionette lines and nasolabial folds). I also use it a lot on lips, because the look is very natural. Restylane is now FDA approved for use in the lips. I personally do not use Juvederm on lips, but on folds.
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